Bioclinic NaturalsDGL 180t
Deglycyrrhizinated licorice, or DGL, has been used clinically for decades, primarily for the treatment of peptic ulcers.1 Licorice has been shown to inhibit several inflammatory enzymes, including both cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), decreasing the production of several potent inflammatory compounds, including prostaglandin E2, thromboxane B2, and leukotriene B4. Importantly, this inhibition is not due to glycyrrhizic acid, the component of licorice which has been removed in DGL, and which is associated with mineralocorticoid excess and hypertension. Another component of licorice, glabridin, has been shown to prevent lipopolysaccharide (LPS) induced production of inflammatory compounds, including nitric oxide and interleukin-1 beta, whereas glycyrrhizic acid has no effect.
Clinically, DGL has been shown to have comparable efficacy to cimetidine for both the healing and prevention of ulcer recurrences. Additionally, extracts of licorice have been shown to inhibit the adhesion of H. pylori to gastric mucosa, as well as the growth of antibiotic resistant strains, suggesting multiple mechanisms of action for its anti-ulcer benefit. The use of chewable tablets appears necessary for DGLs efficacy, as it allows for distribution and absorption by the gastric mucosa.
Benefits
DGL chewable tablets is the form associated with the greatest clinical efficacy, as it allows for licorice to be released in the stomach and dispersed/absorbed by the gastric mucosa
Provides 400 mg DGL per tablet, the clinically effective dosage
Deglycyrrhizination prevents adverse effects associated with licorice consumption
Pleasant tasting tablets for better compliance
Chew 1 tablet per day 20 minutes before each meal or as directed by a health care professional. Consult a health care professional for use beyond 16 weeks.
Serving Size: 1 Tablet
Amount Per Serving
Calories ... 5
Total Carbohydrate ... 1g
Sugar ... 1g
Deglycyrrhizinated Licorice 10:1 Extract ... 400mg
(Glycyrrhiza glabra) (root) (Providing 4000 mg crude herb licorice)
Other ingredients: Dextrose, microcrystalline cellulose, guar gum, purified water, stearic acid, magnesium stearate (vegetable grade).
Contains no artificial preservatives, colors or sweeteners; no dairy, gluten, soy, wheat or yeast.
Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Nearly all contraindications to DGL are due to pseudohyperaldosteronism or mineralocorticoid excess, effects which appear to be primarily due to glycyrrhizic acid. Although there are no apparent contraindications for DGL, patients with hypertension, congestive heart failure and hypokalemia should be monitored carefully. The safety of DGL in pregnancy and breastfeeding is unknown and should be used with caution. Consult a health care professional if you experience persistent stomach or gastrointestinal upset. Keep out of reach of children.
Additional InformationNo known drug interactions. Licorice influences the activity of several cytochrome enzymes, and reduces warfarin activity in animal models, likely due to glycyrrhizic acid activity. Thus DGL use should be carefully monitored in these patients.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.