Pure EncapsulationsSAMe (S-Adenosylmethionine)200 MG60Veggie Caps
Pure EncapsulationsSAMe (S-Adenosylmethionine)200 MG60Veggie Caps
Functions as a donor of methyl groups in over 100 different reactions catalyzed by methyltransferase enzymes, as well as a precursor molecule for glutathione and polyamine synthesis
Supports positive mood and cognitive function
- In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood
- Promotes healthy protein turnover to support healthy CNS function
- Maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity
- Supports neurotransmitter monoamine synthesis and function, including dopamine and serotonin, through SAMe-dependent methylation reactions
Promotes liver function by supporting glutathione production
- Clinical trials indicate that SAMe administration enhances glutathione production in hepatic tissue and red blood cells
Enhances joint comfort by supporting proteoglycan synthesis, as well as helping to stabilize and protect proteoglycans
- In a 16-week randomized, double-blind, placebo-controlled trial involving 56 subjects, SAMe offered statistically significant support for joint comfort
Maintains healthy cell growth and cytokine balance by supporting healthy polyamine production. Provides 200 mg SAMe per capsule to support positive mood, cell membrane fluidity, neurotransmitter synthesis, glutathione production, joint comfort and healthy cell growth.
Pure Encapsulations recommends 1-2 capsules daily, in divided doses, between meals, or as directed by your health care practitioner.
Consult your healthcare provider before use if you are pregnant or nursing, taking antidepressant medication or if you have bipolar disorder. In rare cases, SAMe has been associated with flatulence, nausea, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness. Anxiety and tiredness have occurred in people with depression, and hypomania in people with bipolar disorder. Consult your physician for more information.
SAMe is contra-indicated with anti-depressant medication, dextromethorphan, and meperidine (Demerol). Concurrent use might cause additive serotonergic effects and serotonin syndrome-like effects. It is also contra-indicated with Levodopa. Consult your physician for more information.