In addition to promoting memory and cognitive function, Bacopa monniera maintains healthy enzyme activity in the brain, supporting the ability to deal with stress. In one three–month trial conducted by Australian scientists, bacopa supported learning, minimized stress, and promoted memory. Rhodiola rosea has been used traditionally for hundreds of years to help lessen mental and physical stress and to promote endurance. Similarly, the amino acid l–tyrosine has indicated the potential to promote cognitive function and memory under stressful conditions. Eleutherococcus senticosus, or eleuthero, is used as an adaptogen to help bolster adrenal function and stress resistance. Like ashwagandha, it is highly revered for promoting energy, vitality and immune defense.

Chamomile and lemon balm provide traditional support for calmness and relaxation. B vitamins and magnesium are included to help counter the effects of stress on healthy nutritional status. B–complex vitamins have also been associated with healthy neurotransmitter function and energy metabolism. Vitamin B5 is especially important for boosting healthy adrenal gland function to strengthen the body's ability to withstand stress. Vitamin C provides important support for neutralizing free radicals generated by the stress response.