EPA and DHA from fish oil encourage cardiovascular health by supporting triglyceride and lipid metabolism, maintaining healthy blood flow and promoting healthy platelet function. A randomized, double- blind, placebo-controlled study involving 223 individuals, indicated that fish oil supplementation promotes arterial function. In addition, studies indicate these oils help maintain blood vessel integrity. One study also suggests EPA may moderate protein kinase C, supporting arterial smooth muscle cells. Fish oil is also important for optimal joint function. It moderates prostaglandin and leukotriene production, supporting healthy connective tissue. It also plays a role in moderating neutrophil activity, supporting joint comfort. A double-blind, placebo-controlled, prospective study involving 66 subjects revealed fish oils modulates immune mediator activity as well as provides support for joint flexibility.